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Yes, the Pain Is All in Your Head

New study uses EEG and TMS to measure pain directly from the brain.

F. Perry Wilson, MD MSCE
7 min readJan 27, 2025

I’ve been thinking about Dune a lot lately. I think I might be the only person in the world who prefers the bizarre and grotesque David Lynch movie version to the elegantly crafted Villeneuve oeuvre, including David Lynch himself. We lost a real artist with his passing, and a rewatch of Twin Peaks is very much on my to do list for this winter.

Two Dunes. Source: IMDB

But back to Dune, because one of the pivotal scenes in the novel and both movie versions is one where young Paul Atreides is tested by the Machiavellian Bene Gesserits. He has to put his hand in a box. Inside the box? Pain. Ever increasing pain. He must keep his hand in the box, despite all his instincts telling him to pull it out to prove his fundamental humanity — his ability to exercise control over his own brain.

Because, as the Reverend Mother points out after the ordeal, his hand is unharmed. The pain is a fabrication — pain by nerve induction, she says. There is no physical damage. It’s all in his mind.

And of course, that’s true of all pain isn’t it? It’s not your toe that hurts when…

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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE

Written by F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. Host of "Impact Factor" on Medscape.com.

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