Weight Loss, Even Intentional Weight Loss, Associated with Cancer

Losing weight is hard — success might signal that something else is wrong.

F. Perry Wilson, MD MSCE
6 min readJan 23, 2024

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As anyone who has been through medical training will tell you, some little scenes just stick with you. I had been seeing a patient in our resident clinic in West Philly for a couple of years. She was in her mid-60s with diabetes and hypertension and a distant smoking history. She was overweight, and had been trying to improve her diet and lose weight since I started seeing her, without much luck. One day she came in and was delighted to report she had finally started shedding some pounds — about 15 in the last two months.

I enthusiastically told my preceptor that my careful dietary counseling had finally done the job. She looked through the chart for a moment and said… yeah… is she up to date on her cancer screening? A workup revealed adenocarcinoma of the lung. She did well, actually, but the story… you know… stuck with me.

The textbooks call it “unintentional weight loss”, often in big scary letters and every doctor will go just a bit pale if a patient tells them that, despite efforts not to, they are losing weight.

But true unintentional weight loss is not really that common. After all, most of us are at least half-heartedly trying…

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F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. New book “How Medicine Works and When it Doesn’t” available now.