The Medicines of the Future Will Be Made of RNA

F. Perry Wilson, MD MSCE
6 min readNov 14, 2023

mRNA therapeutics will fundamentally change the practice of Medicine.

Every once in a while, medicine changes in a fundamental way, and we may not realize it while it’s happening. I wasn’t around in 1928 when Fleming discovered penicillin, or in 1953 when Watson, Crick, and Franklin characterized the double-helical structure of DNA.

But looking at Medicine today, there are essentially two places where I think we will see, in retrospect, that we were at a fundamental turning point. One is artificial intelligence, which gets so much attention and hype that I will simply say yes, this will change things, stay tuned.

The other is a bit more obscure, but I suspect it may be just as impactful. That other thing is RNA therapeutics. The medicines of the future.

I want to start with the idea that many diseases are, fundamentally, a problem of proteins. In some cases, like hypercholesterolemia, the body is producing too much protein. In others, like hemophilia, too little.

When you think about disease this way, you realize that our current medications take effect late in the disease game. We have these molecules that try to block a protein from its receptor, or try to prevent a protein from cleaving another protein, or try to…

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F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. New book “How Medicine Works and When it Doesn’t” available now.