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Multisystem Inflammatory Syndrome in Children (MIS-C): Longer Term Outcome Data

F. Perry Wilson, MD MSCE
4 min readSep 2, 2021

The rare condition can be devastating, but fortunately most kids recover.

Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr. F. Perry Wilson of the Yale School of Medicine.

Kids are back in school throughout the country now, and, in many locations, the Delta variant of coronavirus is highly prevalent — raising the possibility of an impending epidemic of covid cases among children too young to be vaccinated.

Overall, though, we know that kids do relatively well with COVID — including with the Delta variant, though recent reports — including this one from the CDC — remind us that most kids who become infected develop at least some symptoms.

MIS-C Symptoms

But early in the pandemic, a spike in cases of a strange inflammatory syndrome in children, usually (but not always) following a known COVID infection emerged. Multisystem Inflammatory Syndrome of Children or MIS-C is characterized universally by persistent fever, but has a slew of other organ system manifestations ranging from nausea, vomiting and…

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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE

Written by F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. Host of "Impact Factor" on Medscape.com.

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