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It’s Not the Chemicals, It’s the Calories

People are missing the point about ultra-processed foods.

F. Perry Wilson, MD MSCE
6 min readFeb 4, 2025

The word “ultra-processed” is doing a lot of heavy lifting when we talk about “ultra-processed food”. It conjures up images of huge factories, machines with vats and tubes, mixing and chopping and amalgamating. It evokes the idea of chemicals, additives, preservatives, colors, flavors. Fundamentally, whatever definition of “ultra-processed” you want to use, it suggests that the inputs to this mechanical behemoth are fundamentally different from the outputs. Food goes in… and something else comes out.

And ultra-processed food is undoubtedly bad for us. At least, we know that people who eat more ultra-processed food have worse health outcomes. And that feels right — it makes sense. Because ultra-processed food is unnatural, right?

When RFK Jr. was testifying before congress last week, he touched on the health impacts of ultra-processed food but buried the lede by focusing on those chemicals and additives, those colors and flavors.

He noted that our foods have more ingredients than similar products in Europe, that our FDA has a longer list of approved additives than similar agencies in other countries. The implication is that maybe the products would be ok, if we could just get rid of red dye number 40 or…

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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE

Written by F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. Host of "Impact Factor" on Medscape.com.

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