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A Review of (For Now) Every Hydroxychloroquine Randomized Trial for Covid-19

F. Perry Wilson, MD MSCE
10 min readAug 5, 2020

Five negative RCTs and one negative pre-print do not a miracle cure make.

This week, I am going against the advice of my loved ones who feel my pain as I read some pretty rough comments online to try and address the hydroxychloroquine issue.

I know, I know.

Just a sampling

Whenever I discuss hydroxychloroquine, people come out of the woodwork to tell me what a bad doctor I am. Even when I made a video simply demonstrating how searching pubmed.gov works, I got some pretty rough replies.

But I guess I’m a glutton for punishment. So I have set out today to collect, in one place, the randomized trials that have been conducted that form the centerpiece for why doctors like me and Anthony Fauci don’t think hydroxychloroquine works for COVID-19.

Now, before we get started…

I am not paid by any pharmaceutical company, nor do I hold a patent on any drug or device. My grant funding comes from the NIH and the Department of Defense. My NIH studies have nothing to do with drugs. My DOD study, in fact…

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F. Perry Wilson, MD MSCE
F. Perry Wilson, MD MSCE

Written by F. Perry Wilson, MD MSCE

Medicine, science, statistics. Associate Professor of Medicine and Public Health at Yale. Host of "Impact Factor" on Medscape.com.

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